Cisplatin and aki and autophagy

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August undefined, 2024

WebMay 30, 2024 · In this study, we detected a persistent autophagy activation in mouse kidneys after nephrotoxicity of repeated low dose cisplatin (RLDC) treatment. 3-methyladenine (3-MA) and chloroquine (CQ), respective inhibitors of autophagy at the initiation and degradation stages, blocked autophagic flux and improved kidney repair in … WebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ …

Potential Therapeutic Targets for Cisplatin-Induced …

WebAdministration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been … WebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury and preserve renal function. Using fluorescence microscopic imaging and fluorine magnetic resonance … simpsons map of springfield

PIM1激酶在顺铂诱导的急性肾损伤中的作用

WebNov 26, 2024 · The inhibition of cisplatin-induced autophagy increases cisplatin-induced apoptosis, suggesting the synergistic induction on cancer cell death via inhibiting cisplatin-induced autophagy activity [39,43]. Thus, through the inhibition of chemotherapy-induced autophagy, ginkgolic acids can enhance the sensitivity of cancer cells to chemotherapy. WebCisplatin, a chemotherapeutic agent, is a known nephrotoxin and can cause AKI. The cisplatin treatment induces a time-dependent increase in the LC3 expression in proximal tubular epithelial cells. 23 The inhibition of autophagy through either treatment with 3-MA or knockdown of Becn1 by short-hairpin RNA or siRNA, or Atg5 by siRNA resulted in ... WebNov 30, 2024 · In this study, we investigated whether canagliflozin protects against cisplatin-induced AKI, depending on adenosine monophosphate-activated protein kinase (AMPK) activation and following... simpsons mathemagician

Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute …

Canagliflozin protects against cisplatin-induced acute kidney injury …

WebThe apoptosis induced by cisplatin in mice increased evidently compared with the control group, which was decreased in the mice with neferine pretreatment. What' more, we found that autophagy increased obviously in mice pretreated by neferine contrast to … WebThe delivery of an approved agent such as rapamycin in a PFC NP format enhances local delivery and offers a novel mechanism-based prophylactic therapy for cisplatin-induced acute kidney injury. For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10–20% of all cancer patients. … simpsons math bookWebAutophagy is induced in proximal tubules during cisplatin nephrotoxicity in C57BL/6 mice C57BL/6 mice (male, 8–10 weeks old) were injected with 25mg/kg cisplatin or saline as control. (A) After the indicated time, kidneys were harvested to collect cortical and outer medulla tissues for immunoblot analysis of LC3 and β-actin (loading control). simpsons mathematik

"WebAug 7, 2024 · Mitophagy is a mechanistically elaborate process including (a) mitophagy initiation, (b) priming of mitochondria for recognition by autophagy machinery, (c) engulfment of the marked mitochondria by formation of the autophagosome, and (d) lysosomal sequestration and hydrolytic degradation ( Figure 1; Vasquez-Trincado et al., … " - Cisplatin and aki and autophagy

Cisplatin and aki and autophagy

Canagliflozin protects against cisplatin-induced acute kidney injury …

WebFeb 18, 2024 · Cisplatin, a platinum-based compound, is a commonly used and highly effective chemotherapeutic agent utilized for the treatment of a variety of solid tumors. … WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, …

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WebCisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

WebApr 6, 2024 · Therefore, it is particularly important to find drugs that have therapeutic effect against cisplatin ototoxicity. Autophagy is a cell metabolic process in which cells degrade their components within lysosomes (or vacuoles) to maintain normal physiological activities and homeostasis ( 7 ). WebJan 22, 2024 · Cisplatin treatment may activate toll-like receptors 2 in renal tubular cells, which further activates autophagy via the phosphorylate phosphoinositide 3-kinase …

WebCisplatin-induced acute kidney injury in mice was established by intraperitoneal injection of cisplatin. The levels of urea nitrogen and creatinine in serum were measured， renal pathology change was assayed by HE staining， qRT-PCR and Western blot were used to detect the expression levels of PIM1 mRNA and PIM1 protein. WebApr 25, 2014 · The role of autophagy in cisplatin-induced AKI is discussed in the next section. 4.2. Autophagy Autophagy is a cellular process of “self-eating” in which …

WebDec 7, 2024 · Genetic ablation of the renal tubular (RT) Atg7 gene or pharmacological inhibition of autophagy suppressed the protective effects of HDAC6. Taken together, our study indicates that HDAC6 contributes to ischemia- and cisplatin-induced AKI by inhibiting autophagy and the acetylation of α-tubulin.

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular … simpsons marge checking computerWebSep 1, 2014 · Pharmacologic induction of autophagy by administrating the mTOR inhibitor, rapamycin or temsirolimus, facilitated renal recovery from AKI during endotoxemia in aged mice [116,119] and pharmacologic inhibition of autophagy with either bafilomycin or 3-methyladenine enhanced cisplatin-induced renal tubular cell death . simpsons math equationWebJul 7, 2024 · The nephrotoxicity of cisplatin remains a major hurdle in the field of oncology. 30% of patients treated with cisplatin develop acute kidney injury (AKI) and all patients … razor clamming washington 2021WebDec 31, 2024 · Special Issue Information. Dear Colleagues, Autophagy (“auto-digestion”), a lysosome-dependent process, degrades and turnovers damaged or senescent organelles and proteins. Autophagy is a highly-regulated process, which impacts several vital cellular responses, including inflammation, cell death, energy metabolism and organelles ... simpsons maternity unit edinburghWebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … simpsons mathWebFeb 2, 2024 · Some scholars have found that in the cisplatin-induced AKI mice, the C. cicadae mycelium extract regulated the inflammatory response by inhibiting renal pathological changes, inflammatory cell infiltration, and the release of a variety of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. razor clamming tides seasideWeb1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ... simpsons mathematical secrets