Thiotepa stability
WebAim and objectives Due to lack of long-term stability data for newly formulated Thiotepa Riemser RTA solutions, the physicochemical in-use stability of diluted infusion solutions … WebAug 1, 2000 · N,N′,N′′-triethylenethiophosphoramide (thioTEPA) is a trifunctional alkylating agent with a broad spectrum of antitumour activity developed in the 1950s. The drug is now experiencing renewed interest as it appears to be one of the most effective anticancer drugs in high dose regimens. ... Stability of thioTEPA (lyophilised) in 0.9% sodium ...
Thiotepa stability
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WebThiotepa for Injection, USP Safety Data Sheet (SDS) July 24, 2024 SDS No.: SDS 095 SDS Version No.: 1.0 Form No.: R-SOP-009-F001 Page: 5of 9 (o) Partition Coefficient: n-octanol/water 0.53 (p) Auto-ignition Temperature Not available (q) Decomposition Temperature Not available (r) Viscosity Not available Section 10 -Stability and Reactivity WebAug 1, 2000 · Despite many years of experience with thioTEPA, pharmacologic data are incomplete and controversy remains with respect to the dose-dependent pharmacokinetics of thioTEPA. In recent years greater insight has been obtained into the metabolism of thioTEPA, but there is still a gap between the total urinary excretion of thioTEPA and …
WebStability: At temperatures above 2–8°C, thiotepa polymerizes and becomes inactive. The bulk drug is stable (up to two years) at 2–8°C, is unstable in acid and is sensitive to light. Aqueous solutions of 10 mg/ml are stable … WebN,N',N"-Triethylenethiophosphoramide (thiotepa) was dissolved at 100 micrograms/ml in urine or in 0.1 M sodium acetate buffer and incubated at 37 degrees or 22 degrees. After 0, 15, 30, 60, 90, and 120 min of incubation, 0.1-ml samples were extracted into ethyl acetate and analyzed by gas-liquid chr …
WebMay 10, 2000 · The stability of thioTEPA-mercapturate was studied in urine adjusted to pH 4,5 or 6 with acetic acid or sodium hydroxide at a concentration of 20 μg/ml. Samples … WebNov 15, 1997 · The stability of thiotepa in a new formulation of the drug was studied. Vials of Thioplex (Immunex), a relatively new lyophilized formulation of thiotepa, were reconstituted with sterile water and diluted with 0.9% sodium chloride injection in polyvinyl chloride infusion bags to thiotepa concentrations of 0.5, 1, and 3 mg/mL. The solutions …
WebNov 15, 1996 · The stability of thiotepa (lyophilized) 0.5 and 5 mg/mL in 5% dextrose injection was studied. Vials of lyophilized thiotepa were reconstituted with sterile water …
WebJan 17, 2024 · Thiotepa concentrations were determined using a stability-indicating RP-HPLC assay. In parallel, pH and osmolality were measured. Sub-visible particles were counted on day 0 and 14. dj moto 東京 喧嘩WebFeb 14, 2012 · N,N′,N″-triethylenethiophosphoramide (Thiotepa) and its oxo analogue (Tepa) as the major metabolite are trifunctional alkylating agents with a broad spectrum of antitumor activity. In vivo and vitro studies show alkylation of DNA by Thiotepa and Tepa can follow two pathways, but it remains unclear which pathway represents the precise … dj moto 東京WebMay 10, 2000 · The influences of pH and temperature on the stability of thioTEPA and its metabolites were studied. An increase in degradation rate was observed with decreasing pH as measured for all studied metabolites. In urine the rate of degradation at 37 degrees C was approximately 2.5+/-1 times higher than at 22 degrees C. At 37 degrees C thioTEPA and ... dj moto 店WebThiotepa was administered intrathecally (IT) at a total dose of 10 mg associated with 40 mg of methylprednisolone weekly until a CNS response or disease progression. A median … dj moto 現在WebNov 1, 2024 · Thiotepa is a synthetic product with antitumor activity. The chemical name for Thiotepa is Tris(1-aziridinyl)phosphine sulfide. Thiotepa has the following structural … dj motionWebA method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by … dj motomixWebMay 10, 2000 · The stability of thioTEPA and its metabolites in urine and plasma strongly depends on the pH (Table 1), showing increased degradation at lower pH. The degradations followed pseudo-first order kinetics. Degradation rates in urine at 22°C are approximately 1.5–3 times lower than at 37°C. ThioTEPA and TEPA were far more stable in plasma than ... dj motoca